Bottner, Mewes,Reindl, Andreas,Lang, Christine,Veen, Markus
申请号：
AU2007334850
公开号：
AU2007334850C1
申请日:
2007.12.18
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates to the use of a microorganism belonging to the groupof lactic acid bacteria or a mutant or derivative thereof, characterized in thatit is capable of specifically binding to a bacterium belonging to the group ofmutans Streptococci, wherein the specific binding is (i) resistant to heat treatment；and/or (ii) resistant to protease treatment； and/or (iii) calcium-dependent；and/or (iv) formed within a pH range between 4.5 and 8.5； and/or (v) formed in thepresence of saliva, for the preparation of an anticariogenic composition forthe treatment or prevention of caries caused by mutans Streptococci other thanStreptococcus mutans. Preferably, the specific binding can be assayed as follows:(a) growing said microorganism to stationary phase； (b) mixing said microorganismwith a bacterium belonging to the group of mutans Streptococci which has beengrown to stationary phase； (c) incubating the mixture obtained in step (b) underconditions allowing the formation of aggregates of said microorganism and abacterium of the group of mutans Streptococci； and (d) detecting aggregatesby the occurrence of a pellet. Another aspect of the present invention is a methodof prophylaxis or treatment of caries caused by mutans Streptococci other thanStreptococcus mutans, comprising administering a microorganism belongingto the group of lactic acid bacteria characterized in that said microorganismis capable of specifically binding to a bacterium belonging to the group of mutansStreptococci or a mutant, derivative, analog or fragment of said microorganism.
