Stuible, Matthew,Tremblay, Gilles Bernard,Sulea, Traian,Moraitis, Anna N.,Filion, Mario
申请号：
AU2013293062
公开号：
AU2013293062A1
申请日:
2013.07.17
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Antibodies and antigen binding fragments that specifically binds to Siglec-15 are described herein. These antibodies or antigen binding fragments may have the ability of inhibiting differentiation of osteoclasts and/or the ability of inhibiting the bone resorption activity of osteoclasts. Compositions and cells expressing anti-Siglec-15 antibodies or antigen binding fragments are also disclosed herewith. Anti-Siglec-15 antibodies may also be useful for the treatment of bone loss, or bone diseases. Methods for the detection or diagnosis of bone loss or bone-related diseases are also described.
