MATTHEW STUIBLE,GILLES, BERNARD TREMBLAY,TRAIAN SULEA,ANNA, N. MORAITIS,MARIO FILION
申请号：
HK15110989.5
公开号：
HK1210192A
申请日:
2015.11.06
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
Antibodies and antigen binding fragments that specifically binds to Siglec-15 are described herein. These antibodies or antigen binding fragments may have the ability of inhibiting differentiation of osteoclasts and/or the ability of inhibiting the bone resorption activity of osteoclasts. Compositions and cells expressing anti-Siglec-15 antibodies or antigen binding fragments are also disclosed herewith. Anti-Siglec-15 antibodies may also be useful for the treatment of bone loss, or bone diseases. Methods for the detection or diagnosis of bone loss or bone-related diseases are also described.
