GUICHERIT, OIVIN M.,BOYD, EDWARD ANDREW,BRUNTON, SHIRLEY ANN,PRICE, STEPHEN,STIBBARD, JOHN HARRY ALEXANDER,MACKINNON, COLIN H.
申请号：
CA2587489
公开号：
CA2587489C
申请日:
2005.11.03
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention makes available methods and reagents for inhibitingaberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-functionor smoothened gain-of-function comprising contacting the cell with a hedgehogantagonist, such as a small molecule, in a sufficient amount to aberrantgrowth state,e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehogactivity.(see formula I)
