Oivin M. Guicherit;Shirley Ann Brunton;Stephen Price;Colin H. Mackinnon;Edward Andrew Boyd;John Harry Alexander Stibbard
发明人:
Oivin M. Guicherit,Edward Andrew Boyd,Shirley Ann Brunton,Stephen Price,John Harry Alexander Stibbard,Colin H. Mackinnon
申请号：
US12848466
公开号：
US08168653B2
申请日:
2010.08.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
