Aqueous pharmaceutical composition comprising a biological therapeutic agent and guanidine or a guanidine derivative, and an injection containing the composition

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专利权人:

ノバルティス アーゲー

发明人:

シュミット， デイビッド,ウォルニー， ハンス－ヨアヒム,シュミット, デイビッド,ウォルニー, ハンス-ヨアヒム

申请号：

JP2015513185

公开号：

JP6250646B2

申请日:

2013.05.23

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention is directed to an aqueous pharmaceutical composition, particularly an aqueous ophthalmic composition, suitable as an injection, particularly an intravitreal injection. The composition includes a biologic therapeutic agent (e.g., an isolated monoclonal antibody that specifically binds to a C5 protein) that tends to raise the viscosity of the composition and a guanidine and/or guanidine derivative (e.g., L-arginine) that tends to lower the viscosity of the composition.

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中国工程科技知识中心

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