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Aqueous pharmaceutical composition containing a biologic therapeutic agent and guanidine or a guanidine derivative and an injection including the composition
专利权人:
Novartis AG
发明人:
David Schmitt,Hans-Joachim Wallny
申请号:
US13900724
公开号:
US10010513B2
申请日:
2013.05.23
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention is directed to an aqueous pharmaceutical composition, particularly an aqueous ophthalmic composition, suitable as an injection, particularly an intravitreal injection. The composition includes a biologic therapeutic agent (e.g., an isolated monoclonal antibody that specifically binds to a C5 protein) that tends to raise the viscosity of the composition and a guanidine and/or guanidine derivative (e.g., L-arginine) that tends to lower the viscosity of the composition.
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