AQUEOUS PHARMACEUTICAL COMPOSITION CONTAINING A BIOLOGIC THERAPEUTIC AGENT AND GUANIDINE OR A GUANIDINE DERIVATIVE AND AN INJECTION INCLUDING THE COMPOSITION

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专利权人:

Novartis AG

发明人:

Schmitt, David,Wallny, Hans-Joachim

申请号：

AU2018203929

公开号：

AU2018203929A1

申请日:

2018.06.04

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

#$%^&*AU2018203929A120180621.pdf#####ABSTRACT The present invention is directed to an aqueous pharmaceutical composition, particularly an aqueous ophthalmic composition, suitable as an injection, particularly an intravitreal injection. The composition includes a biologic therapeutic agent (e.g., an isolated monoclonal antibody that specifically binds to a C5 protein) that tends to raise the viscosity of the composition and a guanidine and/or guanidine derivative (e.g., L-arginine) that tends to lower the viscosity of the composition.

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