Gene transfer into airway epithelial stem cells using lentiviral vectors pseudotyped with RNA or DNA virus spike proteins

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专利权人:

株式会社ＩＤファーマ;株式会社IDファーマ

发明人:

見供 克之,井上 誠,岩崎 仁,長谷川 護,アルトン エリック ダブリュ,グリーセンバッハ ウタ

申请号：

JP2012228651

公开号：

JP5776662B2

申请日:

2012.10.16

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/