Katsuyuki Mitomo,Makoto Inoue,Hitoshi Iwasaki,Mamoru Hasegawa,Eric W. Alton,Uta Griesenbach
申请号：
US15179492
公开号：
US20160281109A1
申请日:
2016.06.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.
