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SUBSTITUTED AROMATIC COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, LIVER FIBROSIS,SKIN FIBROSIS AND CARDIAC FIBROSIS
专利权人:
PROMETIC PHARMA SMT LIMITED
发明人:
Lyne GAGNON,Pierre LAURIN,Brigitte GROUIX,Lilianne GEERTS,François SARRA-BOURNET,Martin LEDUC
申请号:
US15852977
公开号:
US20180134649A1
申请日:
2017.12.22
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula:or a pharmaceutically acceptable salt thereof, whereinA is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4;R1 is H, OH or F;R2 is H, OH, F or CH2—OH;R3 is H, OH, F or CH2Ph;R4 is H, OH or F;Q is 1) (CH2)mC(O)OH wherein m is 1 or 2,2) CH(CH3)C(O)OH,3) C(CH3)2C(O)OH,4) CH(F)—C(O)OH,5) CF2—C(O)OH, or6) C(O)—C(O)OH.
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中国工程科技知识中心
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