The invention relates to a biocompatible, oxygen scavenging tissue graft for repair and regeneration of tissue injury. The oxygen scavenging tissue graft induces a transient, local hypoxic environment that induces the surrounding tissue to upregulate endogenous pro-angiogenic growth factors to enhance the regenerative capacity of the tissue graft and aid in the healing of the tissue injury once the graft is implanted into a host.
