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Drugs for promoting functional regeneration of damaged tissues
专利权人:
株式会社ジェノミックス;国立大学法人大阪大学
发明人:
玉井 克人,山崎 尊彦,知野 剛直,金田 安史
申请号:
JP2010510169
公开号:
JP5814549B2
申请日:
2009.04.30
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The present inventors assessed the possibility that bone marrow-derived cells are mobilized to the grafted skin from nonskin tissues and contribute to skin tissue regeneration during the engraftment of grafted skin on biological tissues. As a result, the present inventors for the first time in the world demonstrated that: (1) a large number of bone marrow-derived cells are mobilized to grafted skin; (2) mobilized bone marrow-derived cells differentiate into any of dermal fibroblasts, adipocytes, muscle cells, vascular endothelial cells, and epidermal keratinocytes in grafted skin, and thus mobilized bone marrow-derived cells include bone marrow-derived mesenchymal stem cells; (3) S 100A8 and S 100A9 released from necrotic tissues of grafted skin are responsible for mobilizing bone marrow-derived mesenchymal stem cells to the grafted skin from peripheral blood; and (4) purified S100A8 and S100A9 promote the migration of mesenchymal stem cells isolated/cultured from the bone marrow.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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