БРИТО Луис (US),ЧАНЬ Мишелль (US),ДЖИЛЛ Эндрю (US),О'ХЭГАН Дерек (US),СИНГХ Манмохан (US),ОХЭГАН Дерек (US)
申请号：
RU2014104092/15
公开号：
RU2014104092A
申请日:
2012.07.06
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. An immunogenic oil-in-water cationic emulsion comprising emulsion particles containing an oil core and a cationic lipid, and a nucleic acid molecule complexing with emulsion particles, where the average diameter of the emulsion particles is from about 80 nm to 180 nm, and the ratio N / P in this emulsion is at least 4: 1, provided that said nucleic acid molecule does not encode secreted alkaline phosphatase, and provided that said nucleic acid molecule is not a molecule loi RNA encoded by plasmid A317, the sequence of which is shown in Figure 7A U.S. Patent Application № 61 / 361892.2. An immunogenic cationic oil-in-water emulsion according to claim 1, wherein said nucleic acid molecule encodes an antigen. An immunogenic cationic oil-in-water emulsion according to claim 1, wherein said nucleic acid molecule is RNA. 4. An immunogenic cationic oil-in-water emulsion according to claim 3, wherein said RNA is autoreplicating RNA. 5. The immunogenic cationic oil-in-water emulsion according to claim 1, wherein said immunogenic cationic oil-in-water emulsion is buffered and has a pH of from about 6.0 to about 8.6. The immunogenic oil-in-water cationic emulsion according to claim 5, wherein said oil-in-water immunogenic cationic emulsion comprises a buffer selected from the group consisting of citrate buffer, succinate buffer, acetate buffer, and combinations thereof. The immunogenic cationic oil-in-water emulsion according to claim 5, wherein said buffer is a citrate buffer and has a pH of about 6.5.8. Immunogenic cationic emulsion of the type1. Иммуногенная катионная эмульсия типа «масло в воде», включающая эмульсионные частицы, содержащие масляную сердцевину и катионный липид, и молекулу нуклеиновой кислоты, образующую комплекс с эмульсионными частицами, где средний диаметр эмульсионных частиц составляет приблизительно от 80 нм до 180 нм, а отношение N/P в этой эмульсии составляет по меньшей мере 4:1, при условии, что указанная молекула нуклеиновой кислоты не кодирует
