THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;DANA-FARBER CANCER INSTITUTE, INC.
发明人:
MULLER, FLORIAN, L.,FLETCHER-SANANIKONE, ELIOT,COLLA, SIMONA,AQUILANTI, ELISA,DEPINHO, RONALD
申请号：
EP12858619
公开号：
EP2790738A4
申请日:
2012.12.14
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor. In some aspects, a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor.
