Board of Regents, The University of Texas System;Dana-Farber Cancer Institute, Inc.
发明人:
Florian L. Muller,Eliot Fletcher-Sananikone,Simona Colla,Elisa Aquilanti,Ronald DePinho
申请号：
US14365367
公开号：
US09452182B2
申请日:
2012.12.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor. In some aspects, a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor.
