THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;DANA FARBER CANCER INSTITUTE INC.
发明人:
MULLER FLORIAN L.,FLETCHER SANANIKONE ELIOT,COLLA SIMONA,AQUILANTI ELISA,DEPINHO RONALD
申请号：
IN5803DEN2014
公开号：
IN5803DEN2014A
申请日:
2014.07.11
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor such as an enolase inhibitor. In some aspects a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor.
