The Board of Regents of The University of Texas System;Dana-Farber Cancer Institute, Inc.
发明人:
Muller, Florian L.,Fletcher-Sananikone, Eliot,Colla, Simona,Aquilanti, Elisa,Depinho, Ronald
申请号：
HRP20191607
公开号：
HRP20191607T1
申请日:
2019.09.05
申请国别(地区):
HR
年份:
2019
代理人:
摘要：
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor. In some aspects, a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor.
