Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid and includes means for directional release of medication into the lacrimal fluid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye.本發明所揭示的為淚管嵌入件及其用以將用藥投遞至眼部之方法。該塞包括一本體部分,該本體部分之尺寸係設計為可通過淚點,並定位於眼瞼之淚小管中,且包含用於用藥之定向投劑至淚液之裝置。該淚管塞可包含一核心或貯藏器,於該本體部分中至少部分包含一治療劑,此療效劑係配置為可受控釋放至眼部。55...通道/通道、孔或其他特徵600...淚管嵌入件