Disclosed are lacrimal inserts and their method of use for delivery of of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye and is configured to release medication via a designated port, valve, or orifice in the insert housing and inhibits diffusion of medication via the housing itself. The core may include retention features to ensure that it remains securely located within the lacrimal insert over its usable life.本發明提供用於傳送藥物至眼部之淚管嵌入物及其使用方法。本發明之淚管塞包括一可通過淚點並置入眼瞼淚小管之主體。該塞可含有至少部分地在主體部分內之一核心或貯藏器,其包含一治療劑,該治療劑係被構形以控制釋入眼部,且被構形以經由在嵌入物外殼中之一特定的孔、閥或孔口釋放藥物,且抑制經由外殼本身之藥物的擴散。核心可包括保持特徵,以確保其整個使用壽命期間均維持穩固地被定位在淚管嵌入物內。10...主體/外殼35...凸緣/端緣45...貯藏器/腔穴/內腔穴/藥物核心腔穴50...外殼/內表面65...第一端/箭頭部分75...開口/裝置的開放端90...藥物核心100...淚管塞/淚管嵌入物105...鎖定環/多個鎖定環150...保持特徵
