Colin M. Tice;Yuanjie Ye;Salvacion Cacatian;Linghang Zhuang;Suresh B. Singh;David A. Claremon
发明人:
David A. Claremon,Linghang Zhuang,Yuanjie Ye,Suresh B. Singh,Colin M. Tice,Salvacion Cacatian
申请号：
US12863634
公开号：
US08592409B2
申请日:
2009.01.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates to novel compounds of the Formula (I), (Ia), (Ic), (Ie), (If), (Ig), (Ih), (Ii), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
