Colin M. Tice;Yuanjie Ye;Linghang Zhuang;Katerina Leftheris;Suresh B. Singh;David A. Claremon
发明人:
David A. Claremon,Linghang Zhuang,Katerina Leftheris,Colin M. Tice,Yuanjie Ye,Suresh B. Singh
申请号：
US12990309
公开号：
US08242111B2
申请日:
2009.04.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention relates to novel compounds of a structural formula selected from:pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals, e.g., diabetes mellitus and obesity. Values for the variables in the structural formulas are provided herein. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
