David A. Claremon,Linghang Zhuang,Katerina Leftheris,Colin M. Tice,Zhenrong Xu,Yuanjie Ye,Suresh B. Singh,Salvacion Cacatian,Frank Himmelsbach,Matthias Eckhardt,Wei Zhao
申请号：
US12990306
公开号：
US08569292B2
申请日:
2009.04.30
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates to novel compounds of the Formula I, Ik, Iq1-21, Ir1-21, Is1-21, It1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
