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Substituted dihydropyrazolones for the treatment of cardiovascular diseases
专利权人:
Bayer Intellectual Property GmbH
发明人:
Thede, Kai,Flamme, Ingo,Oehme, Felix,Ergüden, Jens-Kerim,Stoll, Friederike,Schuhmacher, Joachim,Wild, Hanno,Kolkhof, Peter,Beck, Hartmut,Keldenich, Jörg,Akbaba, Metin,Jeske, Mario
申请号:
ES11175197
公开号:
ES2621787T3
申请日:
2007.10.12
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I) ** Formula ** in which R1 represents a heteroaryl group of formula ** Formula ** in which * means the junction points with the dihydropyrazzolone ring, and R4 means hydrogen, fluorine, chlorine, bromine, cyano, (C1-C4) alkyl, trifluoromethyl, hydroxymethyl, (C1-C4) alkoxy, trifluoromethoxy, hydroxycarbonyl or (C1-C4) -carbonyl alkoxy, R2 represents a heteroaryl group of formula ** Formula ** in which means the junction points with the dihydropyrazzolone ring, and R6, R6A and R6B are the same or different and independently mean each other hydrogen or a substituent selected from the group of fluorine, chlorine, bromine, cyano, (C1-C6) alkyl, trifluoromethyl, hydroxy, (C1-C6) alkoxy, trifluoromethoxy, amino, mono (C1-C4) alkyl-amino, dialkyl (C1-C4) -amino, hydroxycarbonyl, (C1-C4) alkoxycarbonyl and heterocycloalkyl of 4 to 6 members, where (C1-C6) alkyl can be substituted with hydroxy, (C1-C4) alkoxy or amino, and heterocyc on the other hand, the 4- to 6-membered alkyl may be substituted once or twice, the same or differently, with fluorine, cyano, (C1-C4) alkyl, trifluoromethyl, hydroxy, (C1-C4) alkoxy, oxo, amino, mono- (C1-C4) alkyl-amino, di-(C1-C4) -amino, hydroxycarbonyl and / or (C1-C4) alkoxycarbonyl, and R3 represents hydrogen, as well as its salts, solvates and solvates of the salts.Compuesto de fórmula (I)**Fórmula** en la que R1 representa un grupo heteroarilo de fórmula**Fórmula** en las que * significa los puntos de unión con el anillo de dihidropirazolona, y R4 significa hidrógeno, flúor, cloro, bromo, ciano, alquilo (C1-C4), trifluorometilo, hidroximetilo, alcoxi (C1-C4), trifluorometoxi, hidroxicarbonilo o alcoxi (C1-C4)-carbonilo, R2 representa un grupo heteroarilo de fórmula**Fórmula** en la que significa los puntos de unión con el anillo de dihidropirazolona, y R6, R6A y R6B son iguales o distintos y significan independientemente uno de otro hidrógeno o un sustituyente seleccionado del grupo de flúor, cloro, bromo, ciano, a
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