MC GOWAN, David,RABOISSON, Pierre,JONCKERS, Tim,LAST, Stefaan,EMBRECHTS, Werner,PIETERS, Serge
申请号：
ES12721852
公开号：
ES2663601T3
申请日:
2012.05.18
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I) ** (See formula) ** or one of its pharmaceutically acceptable salts, solvates or polymorphs, where R1 is C4-8 alkyl substituted with a hydroxyl, R2 is hydrogen, halogen, hydroxyl, amine, alkyl C1-7, C1-7 alkylamino, C1-6 alkoxy, (C1-4 alkoxy) - (C1-4 alkyl), C3-6 cycloalkyl, C4-7 heterocycle, aromatic moiety, bicyclic heterocycle, arylalkyl, heteroaryl, heteroarylalkyl, carboxylic amide, carboxylic ester each of which is optionally substituted with one or more substituents independently selected from halogen, hydroxyl, amino, C1-6 alkyl, C1-6 dialkylamino, C1-6 alkylamino, C1-6 alkyl, C1- alkoxy 6, C3-6 cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile, R3 is hydrogen, halogen, hydroxyl, amine, C1-7 alkyl, C1- alkenyl 7, C1-7 alkynyl, C1-7 alkylamino, C1-6 alkoxy, (alkoxy C1-4) - (C1-4 alkyl), C3-6 cycloalkyl, C4-7 heterocycle, aromatic moiety, bicyclic heterocycle, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, heteroaryloxy, ketone, nitrile each of which is optionally substituted with one or more substituents independently selected from halogen, hydroxyl, amino, C1-6 alkyl, C1-6 dialkylamino, C1-6 alkylamino, C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkyl, carboxylic acid, carboxylic ester, amide carboxylic, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile, R 4 is hydrogen, halogen, hydroxy, amine, C 1-7 alkyl, C 1-7 alkylamino, C 1-6 alkoxy, (C 1-4 alkoxy) - (C1-4 alkyl), C3-6 cycloalkyl, C4-7 heterocycle, bicyclic heterocycle, arylalkyl, heteroarylalkyl, aryloxy, heteroaryloxy each of which is optionally substituted with one or more substituents independently selected from halogen, hydroxyl, amino, alkyl C1-6, say C 1-6 alkylamino, C 1-6 alkylamino, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl
