GABRIELE AMARI,ELISABETTA ARMANI,ANDREA RIZZI,CHARLES BAKER-GLENN,WESLEY BLACKABY,BEN WHITTAKER,HERVE VAN DE PEL,MAURO RICCABONI
申请号：
ARP130104492
公开号：
AR093795A1
申请日:
2013.12.04
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compounds that can act as inhibitors of the Enzyme phosphodiesterase 4 (PDE4) and Muscarinic m3 Receptor Antagonists, compositions containing same and their use in therapy.Claim 1: wherein is a compound of formula (1) where W is selected from aryl and heteroaryl； r u00b9 is Hydrogen or is selected from the group consisting of: c u2081 u208b u2084 Halogen, alkyl, alkoxy c u2081 u208b u2084, haloalquilo c u2081 u208b u2084, so u2082nr u2076r u2077 hydroxy -, - CN, - nr u2078s - o u2082r u2079, nr u2076r u2077,- conr u2076r u2077 and nr u2078cor u2079 alkyl - and where c u2081 u208b u2084 is optionally substituted with one or more selected from c u2083 u208b u2087 cycloalkyl groups, Hydroxy and alkoxy - nr u2076r u2077 and where c u2081 u208b u2084 is optionally substituted with one or more halogens or cycloalkyl groups c u2083 u208b u2087 whereR u2076 is Hydrogen or alkyl c u2081 u208b u2086； r u2077 is Hydrogen or alkyl c u2081 u208b u2086； r u2078 is Hydrogen or alkyl c u2081 u208b u2086； r u2079 c u2081 u208b u2086 is Hydrogen or alkyl； n is an integer in the range between 1 and 3； R u00b2 is Hydrogen or is selected from the group consisting of: Halogen, alkyl c u2081 u208b u2084 C u2081 u208b u2084, alkoxy, haloalquilo c u2081 u208b u2084, hydroxy - so u2082nr u00b9 u2070r u00b9 u00b9,- and CN - nr u00b9 u00b2so u2082r u00b9 u00b3 alkyl and alkoxy and where c u2081 u208b u2084 c u2081 u208b u2084 are optionally substituted cycloalkyl Group with a c u2083 u208b u2087,R u00b9 u2070 is Hydrogen or alkyl c u2081 u208b u2086； r u00b9 u00b9 is Hydrogen or alkyl c u2081 u208b u2086； r u00b9 u00b2 is Hydrogen or alkyl c u2081 u208b u2086； r u00b9 u00b3 is Hydrogen or alkyl c u2081 u208b u2086； M is an integer in the range between 1 and 3； p is 0 OR 1； l u00b9 is a Group ( u209c ch u2082) where t is an integer in the range 0 or between 1 and 3 L u00b2； is a group selected from (ch u2082) Q where q is an integer in the range between 1 and 3, Ortho -, meta -, Ortho -, para -
