LI, JIH HENG,李志恒,李志恒,HUANG, A MEI,黄阿梅,黃阿梅,CHEN, CHUNG YI,陈中一,陳中一,LIEN, PEI JUNG,连培荣,連培榮,LIU, CHIUNG HUI,刘琼惠,劉瓊惠
申请号：
TW100141688
公开号：
TWI448295B
申请日:
2011.11.15
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
What is disclosed in the invention is a preparation method of a supercriticalCinnamomum subaveniumextract, which is made from the material, the dried stem ofC. subavenium. The extract is obtained by extractingC. subaveniumwhich is pulverized as particles with supercritical carbon dioxide fluid. TheC. subaveniumextract or its active ingredient, subamolide A, can be used to inhibit the growth of human urothelial carcinoma cell lines. In addition, theC. subaveniumextract (or subamolide A) is able to synergistically inhibit the growth of human urothelial carcinoma cell lines with cisplatin (CDDP) or gemcitabine (Gem). Therefore, theC. subaveniumextract (or subamolide A) can be an anticancer drug alone, or forms a pharmaceutical composition with CDDP (or Gem) to treat with cancers in respect of urinary system.本發明揭示為一種香桂超臨界二氧化碳萃取物的方法,其係以乾燥的香桂莖部為材料,並以超臨界二氧化碳流體萃取粉碎為顆粒狀之香桂而得到萃取物,該香桂萃取物或其主要成分subamolide A可用於抑制人類泌尿上皮癌細胞之生長。此外,香桂萃取物(或subamolide A)可協同性地與順雙氨雙氯鉑(或吉西他濱)抑制人類泌尿上皮癌細胞之生長。因此,香桂超臨界二氧化碳萃取物或subamolide A可單獨成為抗癌藥物,或是與順雙氨雙氯鉑(或吉西他濱)組合成為對抗與泌尿系統有關癌症之藥物組合物。1...二氧化碳儲存槽2...預冷器3...高壓液態泵4...加熱器5...超臨界萃取槽6...氣液分離槽
