Protease-resistant variants of stromal cell-derived factor 1 in the repair of tissue injury

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专利权人:

ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド

发明人:

リー リチャード,セガーズ ビンセント

申请号：

JP2009534607

公开号：

JP5695318B2

申请日:

2007.10.22

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/