1. An immunogenic composition comprising (i) cholera toxin B (CTB) with a signal peptide containing the amino acid sequence Ala-Pro-Gly-Tyr-Ala-His-Gly or its C-terminal fragment； and (ii) hapten, where the composition is capable of inducing an immune response to an addictive drug. The immunogenic composition according to claim 1, where the immune response to the addictive drug is higher than the immune response to the addictive drug induced by the immunogenic composition identical to the composition according to claim 1, but not containing the specified signal peptide. The immunogenic composition of claim 1, wherein the addictive drug is cocaine. The immunogenic composition of claim 1, wherein the addictive drug is nicotine. An immunogenic composition according to any one of claims 1 to 4, wherein said immunogenic composition comprises an adjuvant. The immunogenic composition of claim 5, wherein said adjuvant is aluminum hydroxide. An immunogenic composition comprising (i) CTB with a signal peptide containing the amino acid sequence Ala-Pro-Gly-Tyr-Ala-His-Gly or its C-terminal fragment； and (ii) nicotine or a derivative thereof, wherein the composition is capable of inducing an immune response to nicotine. The immunogenic composition according to claim 7, wherein the immune response to nicotine is higher than the immune response to nicotine induced by the immunogenic composition identical to the composition according to claim 7, but not containing said signal peptide. An immunogenic composition according to claim 7 or 8, wherein said immunogenic composition comprises an adjuvant. The immunogenic composition of claim 9, wherein said adjuvant is aluminum hydroxide1. Иммуногенная композиция, содержащая (i) холерный токсин B (CTB) с сигнальным пептидом, содержащим аминокислотную последовательность Ala-Pro-Gly-Tyr-Ala-His-Gly или ее С-концевой фрагмент； и (ii) гаптен, где композиция способна индуцировать иммунный ответ на наркотик, вызывающий зависимость.2. Иммуногенна
