ПРИМЕНЕНИЕ ТЕТРАПЕПТИДА Arg-Pro-Gly-Pro В КАЧЕСТВЕ СРЕДСТВА ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ГИПЕРХОЛЕСТЕРИНЕМИИ, СПОСОБ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ГИПЕРХОЛЕСТЕРИНЕМИИ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ГИПЕРХОЛЕСТЕРИНЕМИИ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ
Закрытое акционерное общество "Инновационный научно-производственный центр "Пептоген" (RU)
发明人:
Андреева Людмила Александровна (RU),Зубова Татьяна Алимовна (RU),Григорьева Марина Евгеньевна (RU),Ляпина Людмила Анисимовна (RU),Мясоедов Николай Федорович (RU),Оберган Тамара Юрьевна (RU)
申请号：
RU2013105211/15
公开号：
RU2013105211A
申请日:
2013.02.07
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. Application of the tetrapeptide Arg-Pro-Gly-Pro as a means of prevention and treatment giperholesterinemii.2. A method for preventing and treating hypercholesterolemia, comprising intranasal administration of the drug based on the tetrapeptide Arg-Pro-Gly-Pro in an effective kolichestve.3. A pharmaceutical composition for preventing and treating hypercholesterolemia, comprising a peptide having a cholesterol-lowering effect as an active substance and a pharmaceutically acceptable excipient as a preservative, characterized in that the peptide used in a peptide of general formula Arg-Pro-Gly-Pro, or a pharmaceutically acceptable salt thereof. 4. A composition according to claim 3, characterized in that the content of the peptide or a pharmaceutically acceptable salt thereof is 0.1 ÷ 1.0 wt.%. 5. A composition according to claim. 3 or 4, characterized in that it is suitable for intranasal vvedeniya.6. A composition according to claim 5, characterized in that it is formed as a solution with the following composition: peptide Arg-Pro-Gly-Pro, or a pharmaceutically acceptable salt - 1 ÷ 10 g / l Nipagin - 0.9 ÷ 1.1 g / liter as preservative, distilled water - up to 1 l.7. A process for preparing a pharmaceutical composition for preventing and treating hypercholesterolemia, comprising mixing the active substances and excipients, characterized in that as active substance the peptide use the general formula Arg-Pro-Gly-Pro, or a pharmaceutically acceptable sol.8. A method according to claim 7, characterized in that the content of the peptide or a pharmaceutically acceptable salt thereof is 0.1 ÷ 1.0 wt.%. 9. A method according to claim 7 or 8, characterized in that the composition is prepared in a form suitable for intranasal vvedeniya.10. The method according to claim 9, of1. Применение тетрапептида Arg-Pro-Gly-Pro в качестве средства профилактики и лечения гиперхолестеринемии.2. Способ профилактики и лечения гиперхолестеринемии, включающий интраназальное введение лекарс
