Removal of high molecular weight aggregates using hydroxyapatite chromatography

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专利权人:

Wyeth LLC

发明人:

Sun Shujun,Gallo Christopher,Kelley Brian

申请号：

US200410958595

公开号：

US9469672(B2)

申请日:

2004.10.06

申请国别(地区):

美国

年份:

2016

代理人:

摘要：

This invention relates to the application of hydroxyapatite chromatography to the purification of at least one antibody from a preparation containing high molecular weight aggregates. Further, this invention relates to an integration of ceramic hydroxyapatite chromatography into a combination chromatographic protocol for the removal of high molecular weight aggregates from an antibody preparation.

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中国工程科技知识中心

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http://www.ckcest.cn/home/