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Pirano and substituted furanoquinolines, their preparation and use as medicines
专利权人:
Laboratorios del Dr. Esteve; S.A.
发明人:
DIAZ-FERNANDEZ, José-Luis,CHRISTMANN, Ute
申请号:
ES13702004
公开号:
ES2627530T3
申请日:
2013.01.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of general formula (I): ** Formula ** Where R 1 is an optionally monosubstituted C3-9 saturated or unsaturated cycloalkyl, optionally containing at least one heteroatom as a member of the selected ring of N, O or S, which can be condensing with an optionally mono-substituted mono or polycyclic ring system; R2 is selected from the group consisting of hydrogen; a branched or unbranched, saturated or unsaturated C1-10 aliphatic radical, optionally at least monosubstituted or -CH2R5; R3 and R4 are independently selected from the group consisting of hydrogen; -NO2; -CF3; -OH; -SH; -NR5R6; - CN; a branched or unbranched, saturated or unsaturated C1-10 aliphatic radical, optionally at least monosubstituted; a C3-9 cycloalkyl optionally saturated or unsaturated at least monosubstituted, optionally containing at least one heteroatom as a member of the selected N, O or S ring that can be condensed with an optionally at least monosubstituted mono or polycyclic ring system; a substituted or unsubstituted aryl; -NHC (O) NHR7; -NHC (S) NHR7; -C (O) OR8; -OR9; -NR10C (O) R11; -SR12; -C (O) NR13R14; -SO2NR15R16 or halogen; R5 to R12 are independently selected from hydrogen; a branched or unbranched, saturated or unsaturated C1-10 aliphatic radical, optionally at least monosubstituted; substituted or unsubstituted aryl; C3-9 substituted or unsubstituted cycloalkyl, optionally containing at least one heteroatom as a member of the ring selected from N, O or S that can be condensed with an optionally at least monosubstituted mono or polycyclic ring system; or substituted or unsubstituted heteroaryl that can be condensed with an optionally at least monosubstituted mono or polycyclic ring system; R13 to R16 are independently selected from hydrogen; a branched or unbranched, saturated or unsaturated C1-10 aliphatic radical, optionally at least monosubstituted; substituted or unsubstituted aryl; C3-9 substituted or unsubstituted cycloalkyl, optionally containing at least one het
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