Universidad Nacional de Quilmes;Chemo Research, S.L.
发明人:
LORENZANO MENNA, Pablo,ALONSO, Daniel Fernando,GOMEZ, Daniel Eduardo,COMIN, Julieta
申请号：
ES12774997
公开号：
ES2569721T3
申请日:
2012.10.10
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I) ** Formula ** or a salt thereof, or any of its stereoisomeric forms or a mixture thereof wherein: R1 and R1 'are independently selected from the group consisting of H, alkyl (C1 -C4), CF3, F, Cl, Br, I, CN, OH, NH2, -OCH3, and NO2； with the proviso that at least one of R1 and R1 'are different from H； A is a radical selected from linear or branched (C1-C6) alkyl or one of a known carbocyclic or heterocyclic ring system with 1-2 rings, wherein each of the rings forming the ring system has 5-7 members , each member independently selected from C, N, O, S, CH, CH2, NH； it is saturated, partially unsaturated or aromatic； A being substituted by one or more radicals selected from the group consisting of H, halogen, nitro, cyano, linear or branched (C1-C6) alkyl, (C1-C6) haloalkyl, linear or branched (C2-C6) alkenyl, - OR2, -COR2, -COOR2, -OC (O) R2, -C (O) NR3R4, -NR3R4, -R5NHR6, -SR2, -SOR2, -SO2R2, and -SO2NR3R4； wherein each R2 independently represents H or linear or branched (C1-C4) alkyl, each R3 independently represents H or linear or branched (C1-C4) alkyl, each R4 independently represents H, linear or branched (C1-C6) alkyl, phenyl, pyridine or quinoline； wherein the phenyl, pyridine and quinoline ring system is substituted by one or more radicals selected from H, linear or branched (C1-C4) alkyl, and NH2； R5 and R6 are independently selected from H, linear or branched (C1-C4) alkyl, for use in the treatment of a condition mediated by Rho-GTPase cellular proteins, wherein the Rho-GTPase cellular protein is Rac1 and the condition is a proliferative disorder selected from the group consisting of precancerosis； dysplasia metaplasia； carcinomas of the gastrointestinal or colorectal tract, liver, pancreas, kidney, bladder, prostate, endometrium, ovary, testicles, melanoma, dysplastic oral mucosa, invasive oral cancers, small and non-small cell lung carcinoma, hormone-dependent breast cancers, cancers hormone-independent breast cancers, squamous
