Floris Louis VAN DELFT,Floris Petrus Johannes Theodorus RUTJES,Frederik Jan DOMMERHOLT
申请号：
US16358272
公开号：
US20200048174A1
申请日:
2019.03.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
