VAN DELFT, FLORIS, LOUIS,RUTJES, FLORIS, PETRUS, JOHANNES, THEODORUS,DOMMERHOLT, FREDERIK, JAN
申请号：
DK11720197
公开号：
DK2563753T3
申请日:
2011.04.26
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
