BENTLEY, Michael D.,VIEGAS, Tacey X.,GOODIN, Richard R.,CHENG, Lin,ZHAO, Xuan
申请号：
AU2014280956
公开号：
AU2014280956A1
申请日:
2014.12.24
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2014280956A120150122.pdf#####ABSTRACT The invention provides small molecule drugs that are chemically modified by covalent attachment of a watersoluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition, A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
