#$%^&*AU2014200906B220160707.pdf#####Abstract The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered 5 by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer. 5136858 1 (GHMatters) P81855.AU.1