Bentley, Michael D.,Viegas, Tacey X.,Goodin, Richard R.,Cheng, Lin,Zhao, Xuan
申请号：
AU2012227249
公开号：
AU2012227249B2
申请日:
2012.09.21
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2012227249B220141002.pdf#####ABSTRACT The invention provides small molecule drugs that are chemically modified by covalent attachment of a watersoluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer. 2242773_1 (GHMatters) 1/06110
