Disclosed is a pharmaceutical composition comprising a water insoluble polymer matrix that comprises a bioerodable polyester polymer or a fatty acid based polyester polymer, or a mixture of both polymers, wherein the polymer matrix has a melting point of less than 60℃, and wherein the composition is liquid or paste at room temperature and is formulated to occlude a punctual channel in a subject and conforms to the shape of the canalicular or punctal channel.揭示一種包含生物可分解聚酯聚合物或脂肪酸化聚酯聚合物之水不可溶聚合物基質的醫藥組成物,或該二種聚合物的混合物,其中該聚合物基質具有低於60℃的熔點,以及其中該組成物在室溫下為液態或糊狀及被配製成可阻塞生物體之淚管並且符合該管狀或淚管的形狀。12...下淚點14...淚小管16...上淚點18...上淚小管19...壺腹21...壺腹22...鼻淚管30、32...組成物