SHEN, HSIN HSIN,沈欣欣,沈欣欣,CHEN, WEN SHIANG,陈文翔,陳文翔,WU, CHUEH HUNG,吴爵宏,吳爵宏,SUN, MING KUAN,孙铭宽,孫銘寬,WANG, YUCHI,王羽淇,王羽淇,CHEN, SEN LU,陈森露,陳森露,YU, WEI LIN,余惟琳,余惟琳,HSU, LIH TAO,徐丽道,徐麗道,LIN, SHIH PING,林诗萍,林詩萍
申请号：
TW107127996
公开号：
TW201927342A
申请日:
2018.08.10
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The disclosure provides a powder form and a hydrogel composition for alleviating degenerative joint and tendon tear. The powder form consists essentially of a 120-380 parts by weight biodegradable copolymer； 15-75 parts by weight urea； and 100 parts by weight platelet-rich plasma； wherein the biodegradable copolymer has a structure of formula (I) or formula (II): , wherein A comprises a hydrophilic polyethylene glycol polymer； B comprises a hydrophobic polyester polymer； BOX is bifunctional group monomer of 2, 2'-bis(2-oxazoline) and used for coupling the blocks AB or BAB； and n is an integer and the same or more than 0.本揭露提供粉體製劑及水膠組合物用於製備減緩退化性關節及修復肌腱斷裂之藥物的用途，其中所述粉體製劑實質上由120重量份至380重量份的生物可分解共聚合物、15重量份至75重量份的尿素、及100重量份的富含血小板血漿(Platelet-Pich Plasma，PRP)所組成，其中所述生物可分解共聚合物符合下列公式(I)或(II)所示結構：其中，A嵌段高分子係為一親水性聚乙二醇聚合物(hydrophilic polyethylene glycol polymer)；B嵌段高分子係為一疏水性聚酯聚合物(hydrophobic polyester polymer)；BOX係為2、2'-雙(2-噁唑啉)(2、2'-bis(2-oxazoline))之雙官能基單體，用以交聯兩團聯A-B或三團聯B-A-B；以及n係為一整數，且n0。
