A surgical instrument with good operability with tissue anastomosis with an endoscope is realized. The surgical instrument (1) of the present invention comprises an insertion unit (2)； an operating unit (3) on the insertion unit； a treatment unit (4) which protrudes from the insertion unit； a first shaft member (41) for transmitting turning force to the treatment unit in conjunction with the turning operation of a turning operation member provided on the operating unit； and a second shaft member (42) for transmitting opening-closing force to the treatment unit in conjunction with the opening-closing operation of an opening-closing member on the operating unit； wherein the first and second shaft members are positioned on approximately the same axis； and the treatment unit can turn about the axis in the protruding direction with the turning operation member, and the treatment unit can move at least one of two gripping members, each having a gripping face.
