CHENG, Hengmiao,JOHNSON, Ted William,HOFFMAN, Jacqui Elizabeth,GUO, Lisa Chen,LIU, Zhengyu,JOHNSON, Theodore Otto,LIU, Kevin Kun-Chin
申请号：
ES09787247
公开号：
ES2614130T3
申请日:
2009.09.18
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (I), ** Formula ** in which: R1 is H, (C1 to C6) alkyl, cycloalkyl (C3 to C8), alkenyl (C2 to C8), alkynyl (C2 to C8), aryl (C6 to C14), cycloheteroalkyl (C2 to C9) or heteroaryl (C2 to C9), in which each of said alkyl (C1 to C6), cycloalkyl (C3 to C8), alkenyl (C2 to C8), alkynyl ( C2 to C8), aryl (C6 to C14), cycloheteroalkyl (C2 to C9) and heteroaryl (C2 to C9) is optionally substituted with at least one R6 group； R2 is H, - (CH2) nC (O) OR7, - (CH2) nC (O) N (R8aR8b), (C1 to C6) alkyl, cycloalkyl (C3 to C8), alkenyl (C2 to C8), alkynyl ( C2 to C8), aryl (C6 to C14), cycloheteroalkyl (C2 to C9) or heteroaryl (C2 to C9), in which each of said alkyl (C1 to C6), cycloalkyl (C3 to C8), alkenyl (C2 to C8), alkynyl (C2 to C8), aryl (C6 to C14), cycloheteroalkyl (C2 to C9) and heteroaryl (C2 to C9) is optionally substituted with at least one R6 group； R3 is H or (C1 to C3) alkyl； R and R4 are independently H, halo, cyano or (C1 to C6) alkyl； R5 is H or (C1 to C6) alkyl optionally substituted with at least one R6 group； each R6 is independently -OH, halogen, CF3, - (CH2) nNR8aR8b, (C1 to C6) alkyl, alkenyl (C2 to C8), alkynyl (C2 to C8), alkoxy (C1 to C6), cyano, cycloalkyl (C3 to C8), cycloheteroalkyl (C2 to C9), aryl (C6 to C14), heteroaryl (C2 to C9), - (CH2) nC (O) R9, - (CH2) nS (O) mR9, - (CH2) nS (O) mNR8aR8b, - (CH2) nNR8aS (O) mR9, - (CH2) nC (O) OR7, - (CH2) nC (O) NR8aR8b, - (CH2) nOC (O) R9, - (CH2) nNR8aC (O) R9 or - (CH2) nNR8aC (O) NR8aR8b, wherein each of said alkyl (C1 to C6), alkenyl (C2 to C8), alkynyl (C2 to C8), alkoxy (C1 to C6), cycloalkyl (C3 to C8), cycloheteroalkyl (C2 to C9), aryl (C6 to C14) and heteroaryl (C2 to C9) is optionally substituted with at least one R10 group； each R7 is independently H or (C1 to C6) alkyl optionally substituted with at least one R10 group； R8a and R8b are each independently H, (C1 to C6) alkyl, cycloalkyl (C3 to C8), cycloheteroalkyl (C2 to C9), heteroaryl (C2 to C9) or aryl (C6 to C14) in whi
