METHODE DE SELECTION PAR BIOPANNING UTILISANT DES PROTEINES LEURRES MODIFIEES

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专利权人:

CENTOCOR; INC.

发明人:

O'NEIL, KARYN,SWEET, RAYMOND,HEAVNER, GEORGE

申请号：

CA2564098

公开号：

CA2564098C

申请日:

2005.04.22

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The invention relates to a method of directing selection of biologicaltherapeutic molecules to specific functional domains of the target biologicmolecule. Selection is directed by the use of closely related molecules, whereone is a decoy and the other contains the targeted domain or epitope. Theinvention is based on the use of physical data, which may be combined withderived data, to ascertain that the decoy and the target differ only in thespecific functional domain or epitope where the binding will be directed.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/