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両親媒性コポリマーおよび調節放出の有効成分を基にした微小粒子、ならびにこれらを含む医薬製剤
专利权人:
フラメル・テクノロジーズ
发明人:
アラン・コンスタンシス,ヨー-ピン・チャン
申请号:
JP2009525938
公开号:
JP5302197B2
申请日:
2007.07.30
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
Polymeric microparticle (I) comprising an active ingredient is claimed. The polymer present in (I) is amphiphilic, biodegradable, hydro-soluble copolymer with hydrophobic and hydrophilic groups, spontaneously forms a colloidal suspension of nanoparticles in water at a pH of 7 under isotonic condition. (I) is non-covalently bonded to the active ingredient and obtained by atomization of a solution or a colloidal suspension of (I), has a size of 0.5-100 mu m, preferably 2-40 mu m and is dispersible in colloidal suspension measured by a dispersibility test described in the given specification. Independent claims are included for: (1) a process of preparing (I) comprising atomizing a solution or a colloidal suspension of (I) (2) a liquid/solid pharmaceutical formulation for the sustained release of the active ingredient comprising a less viscous colloidal suspension (3) requirements for a reconstitution process comprising (I) and a reconstituting liquid like an aqueous liquid, water (non)miscible organic liquid and (4) a reconstitution process comprising mixing and agitating the given requirements.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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