TCHERKASSOV ARTEM,RENNIE PAUL S,BAN FUQIANG,LI HUIFANG,LEBLANC ERIC JOSEPH JEAN,DALAL KUSH,TVERDOKHLEBOV ANTON V,BABIY SERGIY,BOGOMOL EVGENIIA,DUNAYENKO KATERYNA
申请号：
IN201637027260
公开号：
IN201637027260A
申请日:
2016.08.09
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
A compound having the structure of Formula I wherein A is a substituted or unsubstituted aryl or heteroaryl group D is a substituted or unsubstituted 5 or 6 membered heteroaryl or heterocyclyl group and E is a substituted or unsubstituted aryl heteroaryl cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate breast ovarian endometrial or blader cancer) hair loss acne hirsutism ovarian cysts polycystic ovary disease precocious puberty and age related macular degeneration. The use of the compounds for the manufacture of a medicament for modulating AR activity a method of treatment using such compounds and a pharmaceutical composition and a commercial package comprising said compounds are also described.
