METHODS OF TREATING NEURODEGENERATIVE DISEASES USING INDANE ACETIC ACID DERIVATIVES WHICH PENETRATE THE BLOOD BRAIN BARRIER

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专利权人:

DARA BioSciences; Inc.

发明人:

Mary Katherine Delmedico

申请号：

US15863498

公开号：

US20180200230A1

申请日:

2018.04.02

申请国别(地区):

US

年份:

2018

代理人:

摘要：

This invention describes the use of indane acetic acid derivatives which are dual PPAR delta/gamma agonists, and which penetrate the Blood Brain Barrier and achieve effective brain to plasma drug levels at non-toxic doses, for the treatment of neurodegenerative diseases including one or more of the following: Alzheimer's Disease (AD)； Huntington's Disease (HD)； Parkinson's Disease (PD)； Amyotrophic Lateral Sclerosis (ALS)； Frontal Temporal Dementia (FTD)； Corticobasal Degeneration (CBD)； Progressive Supranuclear Palsey (PSP)； Dementia with Lewy Bodies (DLB)； or Multiple Sclerosis (MS).

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