This invention describes the use of indane acetic acid derivatives which are dual PPAR delta/gamma agonists, and which penetrate the Blood Brain Barrier and achieve effective brain to plasma drug levels at non-toxic doses, for the treatment of neurodegenerative diseases including one or more of the following: Alzheimer's Disease (AD)； Huntington's Disease (HD)； Parkinson's Disease (PD)； Amyotrophic Lateral Sclerosis (ALS)； Frontal Temporal Dementia (FTD)； Corticobasal Degeneration (CBD)； Progressive Supranuclear Palsey (PSP)； Dementia with Lewy Bodies (DLB)； or Multiple Sclerosis (MS).
