Arizona Board of Regents on behalf of the University of Arizona
发明人:
申请号：
EP16854447.6
公开号：
EP3359151A4
申请日:
2016.10.07
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.
