Peptidomimetic compounds

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专利权人:

发明人:

Renato T. Skerlj,Andrew C. Good

申请号：

US15298768

公开号：

US10011639B2

申请日:

2016.10.20

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to inhibitors of protein-protein interactions (PPI). Specifically, the present invention relates to a structural informatics approach to designing peptidomimetic macrocycles containing an amino acid “warhead” for ligand-directed covalent modification of cysteine and lysine-containing proteins for the treatment of diseases such as cancer. Further included is the targeting of components of the BCL2 signaling pathway, specifically BCL2-A1 and MCL-1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/