KONRADI, Andrei,DOMINY, Stephen S.,CRAWFORD LYNCH, Casey,COBURN, Craig,VACCA, Joseph
申请号：
EP15849799
公开号：
EP3204352B1
申请日:
2015.10.05
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
