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Methods for enhancing the immunostimulation potency of aluminum salt-adsorbed vaccines
专利权人:
The Government of the United States of America as Represented by the Secretary of the Army
发明人:
Alving, Carl R.,Kim, Jerome H.,Rao, Mangala
申请号:
AU2014388299
公开号:
AU2014388299A1
申请日:
2014.07.09
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
Provided herein are (1) a method of mixing an aluminum salt-adsorbed immunogen with a monophosphoryl lipid A (MPLA)-containing liposome (L(MPLA)), and (2) the resulting immunogenic composition. The resulting immunogenic composition has an enhanced immunostimulation potency compared with either a composition comprising the uncapsulated immunogen mixed with the L(MPLA) or the aluminum salt-adsorbed immunogen alone.
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